INOVIO currently has the following clinical trials enrolling. Inovio's clinical programs include HPV/cervical dysplasia and cancer (therapeutic), avian flu (preventive), and HIV vaccines (both preventive and therapeutic). The vaccine is being delivered using Inovio's MedPulser DNA Delivery System. Dr J Joseph Kim, Inovio's CEO, said "This exciting data provides a great foundation for the ongoing COVID-19 vaccine advancement as it demonstrates the power of INOVIO's delivery system and . . Author: production of the immune-system-stimulating protein the vaccine was coded to produce) of . Program. Inovio Pharmaceuticals developed a vaccine and delivery device targeting the SARS-CoV-2 S protein (INO-4800) (Fig. 1 Despite its initial promise, DNA vaccination has shown inferior . Vaccine Delivery Devices Market business document is structured with the thorough market analysis carried out by a team of industry experts, dynamic analysts, skilful forecasters and well-informed . In the . INO-4800, INOVIO's DNA vaccine candidate against SARS-CoV-2, is composed of a precisely designed DNA plasmid that is injected intradermally followed by electroporation using a proprietary smart . Vaccine Delivery Devices Market study has market attractiveness analysis, wherein each segment is benchmarked based on its market size, growth rate, and general attractiveness. This trial is the first Lassa fever candidate vaccine to enter the clinic. BLUE BELL, Pa., Dec. 6, 2012. Disease. Unlike DNA vaccines, mRNA vaccines do not need to enter the nucleus, nor do they risk being integrated into our DNA, and they are directly translated into protein antigens. INOVIO is committed to developing new, innovative DNA medicines to treat diseases with urgent global health needs including cancer and infectious diseases. The DNA vaccine, INO-4800, delivered intradermally with CELLECTRA® electroporation (EP) delivery system, induces a balanced immune response that includes engagement of both T cells . In a nutshell, Inovio delivers genetic material to your system, which acts as a microbiological "recipe." The Company's COVID-19 vaccine candidate INO-4800 is under a phase I study in the U.S., with interim results expected to be available later this month. Inovio has already conducted two separate phase I studies of its universal flu vaccine using the skin EP delivery system and generated broadly protective hemagglutination inhibition (HAI) titers . Also making the vaccine unique, INO-4800 is composed of an optimised DNA plasmid. These vaccines, in combination with Inovio's proprietary electroporation delivery devices, have been shown to be safe and generate significant immune responses. NIAID-funded scientists at University of Pittsburgh School of Medicine tested the vaccine delivery device in mice and published the results April 2 in The Lancet journal EBioMedicine. This exciting data provides a great foundation for the ongoing COVID-19 vaccine advancement as it demonstrates the power of INOVIO's delivery system and the strength of our coronavirus experience. COVID-19 drug delivery system . Inovio Pharmaceuticals is planning to launch a late-stage study in the US of its investigational COVID-19 vaccine in the second quarter of 2021, according to the Financial Post.. The industry report . INOVIO is also planning to advance INO-4500 to a Phase 1b trial in Africa in 2020. INO-4800 is among several vaccines being tested against SARS-CoV-2, the virus that causes COVID-19 disease with the goal of inducing a protective immune response. The company has a candidate, INO-4800 that it . production of the immune-system-stimulating protein the vaccine was coded to produce) of "naked" DNA vaccines by 100-fold or more compared to delivery of naked DNA vaccines via conventional injection alone. "We expect to complete mid-stage trials in March and project we will be able to start late-stage trials in second quarter of this year," Dr . And Inovio impressively rolled out a Covid-19 vaccine candidate, INO-4800, . INOVIO URGENTLY FOCUSED ON DEVELOPING COVID-19 DNA VACCINE Because the World Can't Wait LEARN MORE POWERING DNA MEDICINES ™ INOVIO is focused on rapidly bringing to market precisely designed DNA medicines to potentially treat and prevent a range of serious and life-threatening diseases related to HPV, cancer, and infectious diseases Inovio expects to answer all regulatory questions raised by the FDA regarding its vaccine delivery system by the second quarter, Dr. Joseph Kim, the company's chief executive officer, told Reuters. The vaccine is produced in Texas and a few other locations. Inovio's electroporation systems have been shown to increase cellular uptake of a vaccine by a 1000 times or more and have been shown to be safe and well-tolerated in multiple human studies. The company expects the testing to take about two weeks. Inovio won a $71 million contract from the U.S. Department of Defense to bolster manufacturing of the device it uses to deliver its coronavirus vaccine. Inovio shares sink after FDA places partial hold on Phase II/III Covid-19 vaccine study The company emphasized that the partial hold was due to "additional questions" about the . Inovio's electroporation-based DNA vaccine delivery systems can increase levels of gene expression (i.e. 4) . About INOVIO INOVIO is a biotechnology company focused on rapidly bringing to market precisely designed DNA medicines to treat and protect people from infectious diseases, cancer, and diseases . Inovio Pharmaceuticals Gets $71M for Vaccine-Delivery Device Inovio received $71 million from the Pentagon to ramp output of a device that delivers the coronavirus vaccine into the skin. SynCon uses a proprietary computer algorithm that has been designed to identify and optimize the DNA sequence of the target antigen, whether it is a virus or a tumor. The funds were for its delivery system which will be equally important in getting a vaccine distributed expeditiously. "We expect to complete mid-stage trials in March and project we will be able to start late-stage trials in second quarter of this year," Dr. Kim . As a result, mRNA vaccines require only 1/1000 the dose of DNA vaccines and do not need special delivery devices. This authorization is good news for the biotechnology company who is aiming to test its vaccine, called INO-4800, in conjunction with its delivery system called . Inovio expects to answer all regulatory questions raised by the FDA regarding its vaccine delivery system by the second quarter, Dr. Joseph Kim, the company's chief executive officer, told Reuters. Inovio's candidate, a DNA vaccine, is one of 13 COVID-19 programs worldwide in human testing, according to a Monday update from the World Health Organization. Dr J Joseph Kim, Inovio's CEO, said "This exciting data provides a great foundation for the ongoing COVID-19 vaccine advancement as it demonstrates the power of INOVIO's delivery system and . A key part of the vaccine is the delivery system, CELLECTRA, which is made entirely at Inovio's manufacturing plant in San Diego. Inovio has already conducted two separate phase I studies of its universal flu vaccine using the skin EP delivery system and generated broadly protective hemagglutination inhibition (HAI) titers . Inovio expects to answer all regulatory questions raised by the FDA regarding its vaccine delivery system by the second quarter, Dr. Joseph Kim, the company's chief executive officer, told Reuters. One . With the company promising to produce about . A phase II/III efficacy trial is planned to . Additionally, Inovio's partner Advaccine is sponsoring a booster study in China, where INO-4800 is given as a booster after primary vaccination with an inactivated COVID-19 vaccine. Inovio's SynCon DNA vaccine cannot cause disease, which might happen using current killed viral FMD vaccines because of incomplete virus inactivation. In March 2020, the Bill & Melinda Gates Foundation provided INOVIO a grant of $5 million for testing and scale up of the CELLECTRA ® 3PSP delivery device for the intradermal delivery of INOVIO's DNA COVID-19 vaccine in development (INO-4800).. The shares plunged. Inovio Pharmaceuticals Inc said it had begun testing its vaccine candidate, INO-4800, to evaluate its effectiveness against the new variant. INOVIO is also evaluating INO-4800, a DNA vaccine candidate against COVID-19, in a Phase 2/3 clinical trial; the Phase 3 segment of which has received regulatory approvals to begin in Colombia . Inovio leveraged prior experiences in developing a MERS-CoV vaccine (INO-4700), which shares a global protein fold structure with SARS-CoV-2 . Key Milestone for First-in-Man DNA Vaccine Clinical Trial Using Inovio's Electroporation DNA Delivery Technology SAN DIEGO, CA, USA | May 22, 2007 | Inovio Biomedical Corp. (AMEX: INO), focused on the development of DNA-based vaccines for cancers and infectious diseases and a novel alternative to surgery to treat localized cancers, announced today that interim data from a clinical study of an . Inovio expects to answer all regulatory questions raised by the FDA regarding its vaccine delivery system by the second quarter, Dr. Joseph Kim, the company's chief executive officer, told Reuters. Inovio expects to answer all regulatory questions raised by the FDA regarding its vaccine delivery system by the second quarter, Dr. Joseph Kim, the company's chief executive officer, told Reuters. References: Kate Broderick, Inovio's senior vice president of R&D, has been working on this technique for years, but . 6.3.4 South America 6.3.5 Middle East and Africa 6.4 Global Vaccine Delivery Devices Sales Forecast by Region 2021-2027 6.5 Global Vaccine Delivery Devices Market Value Forecast by Region 2021 . INOVIO's DNA medicines are made using a process called SynCon ®. The advantages of this non-live vaccine platform extend not only into improvements in safety but also into managing logistical concerns, including manufacturing and maintenance. Data released Tuesday from a study of an experimental prostate cancer vaccine showed that Inovio Biomedical's (NASDAQ:INO) delivery system significantly enhanced the vaccine's potency.. All vaccines were administered intramuscularly with Inovio's CELLECTRA electroporation delivery system. Inovio's device uses a technique called electroporation to sneak a DNA vaccine into cells. The INO-4500 program is fully funded through a global partnership with CEPI - the Coalition for Epidemic Preparedness Innovations. standardized) while addressing many of the disadvantages. "We expect to complete mid-stage trials in March and project we will be able to start late-stage trials in second quarter of this year," Dr. Kim . to support its Cellectra 3PSP smart device.. Funding from the DoD is set to support large-scale manufacturing for the Cellectra 3PSP and the procurement of Cellectra 2000 devices, which are used to deliver Inovio's INO-4800 COVID-19 vaccine candidate directly into the skin. The funds were for its delivery system which will be equally important in getting a vaccine distributed expeditiously. Inovio Pharmaceuticals Inc. put a partial hold on a phase 2-3 study of its Covid-19 vaccine after U.S. regulators raised questions about a delivery device used in the inoculation. Inovio Pharmaceuticals () is easily one of the most volatile stocks on the market, thanks in no small part to the company's COVID-19 vaccine, INO-4800. In September 2019, the US Food and Drug Administration (FDA) placed a temporary hold on Inovio's mid-to-late stage trial investigating its vaccine candidate INO-4800.. At that time, the hold was put in place because . That followed a $1.6 million grant in 2016 to back its Zika . Inovio ' s electroporation-mediated DNA delivery system is designed to enhance the potency of DNA-based immunotherapies against cancers and infectious diseases. With the advent of DNA immunization, many challenges associated with more traditional vaccination approaches are being addressed. In December 2016, the Bill & Melinda Gates Foundation awarded INOVIO a $1.6 million sub-grant through The Wistar Institute to develop a DNA-encoded . View INOVIO's DNA Medicines Pipeline. The plasmid vaccine is delivered into muscle tissue with the assistance of electroporation with the goal of achieving . Introduction. The funding will help spur large-scale production of the Cellectra 3PSP device and may pave the way for delivery of hundreds of millions of doses of vaccine next year, Inovio said in a June 23 . As it relates to INO stock, Inovio focuses on nucleic-acid-based vaccines.
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